Di Bello attended the Academy of Fine Arts in Naples. In 1958 he formed Gruppo ‘58 and began to exhibit his work frequently. His first solo show was held in 1966 at Galleria Lucio Amelio in Naples, followed by two further exhibitions in 1970 and 1977. He moved to Milan in 1967, and in 1971 he exhibited at the Venice Biennale and for the first time at Studio Marconi, and subsequently in 1974, 1976, 1978, 1981 and 2003. One of his many, important shows abroad took place in 1974 at the Kunsthalle, Bern.
In 2010, Fondazione Marconi presented a major retrospective of his work, and in 2011 a solo show was held at the Museu de Arte Contemporanea de Niteroi, Rio de Janeiro.
Di Bello lives and works in Milan.